http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170087128-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_865a587bf68560b908ed27b29b48b46a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0002 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0019 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0021 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K38-27 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8bebb64e42d48b7683442eaa9c4d8d83 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e6e4afb61be5f83c8e017d83405a2f37 |
| publicationDate | 2017-07-28-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20170087128-A |
| titleOfInvention | Pharmaceutical composition for rehabilitation of burn survivor containing human growth hormone |
| abstract | Post-burn catabolism during the first 3 weeks increases caloric imbalance and overestimation; Due to energy consumption of about twice the normal limit, significant weight loss occurs. In addition, the size of the burns and the duration of the treatment are related to the duration of the emergency room treatment. Severe burns with longer duration of treatment lead to muscle mass loss, so-called sarcopenia and physical weakness. Possible therapeutic strategies include exercise, anabolic steroids or human growth hormone replacement. To determine the clinical effect of human growth hormone on postprandial hypopyon, we compared the groups receiving human growth hormone subcutaneous injection and placebo prescription during rehabilitation. A total of 33 patients with a third degree burn on more than 20% of the total surface area of the body were randomly divided into a test group (n = 18) and a control group (n = 15) Slow-release human growth hormone was injected and placebo was injected into the control group. Muscle strength, cardiopulmonary function, body composition and body weight were measured immediately after growth hormone or placebo treatment, 1 month and 3 months. The mean age of the hormone - treated group was 37.67 ± 7.64 years and the mean age of the control group was 37.22 ± 8.19 years. The time interval between burn and hormone administration was 123.7 ± 53.6 days, and the interval between burn and placebo administration was 126.6 ± 43.5 days. After 3 months, oxygen consumption, maximal oxygen consumption, dry weight, maximal torque of knee extensor, and insulin-like growth hormone 1 (IGF-1) and adiponectin levels were significantly higher in the hormone treated group than in the control group at the lactate threshold. There was no difference in body weight, systolic and diastolic blood pressure, bone mineral content, body fat percentage and burn scar between the two groups. The results of the present invention indicate that the use of human growth hormone during the rehabilitation period of burn patients is beneficial for the improvement of recovery of burn patients such as physical strength enhancement and dry weight gain through strengthening of muscle strength. |
| priorityDate | 2016-01-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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