| abstract |
The invention wangjine (Scolopendra anti-platelet and anti-adherent pharmaceutical composition comprising as an active ingredient a compound represented by any one of formulas (1), (2) and (3) or a pharmaceutically acceptable salt thereof isolated from subspinipes The compounds represented by Chemical Formulas 1, 2 and 3 are activated partial thromboplastin time (aPTT) and prothrombin time in human umbilical vein endothelial cells (HUVECs) prothrombin time, PT), inhibiting thrombin and activated factor X (FXa), inhibiting thrombin-catalyzed fibrin polymerization and platelet aggregation, inhibiting thrombopoietic model and antithrombotic effect in arterial thrombosis model Inhibits protein kinase C (PKC) activity and calcium mobilization, and inhibits the anticoagulant effect in mice , And by reducing the ratio of plasminogen activator inhibitor-1 (PAI-1) to tissue plasminogen activator (t-PA) Platelet agents and anticoagulants. |