| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1e96496a9949403e2af2ca913e65bfec |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-549
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48092
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-5115
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6929
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-6923
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48861
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-48884 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-88
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-51 |
| filingDate |
2015-11-20-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ea46adce89d34d052cd5f868a164afb0
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5d634c87702d1df1e7e3aa8af68aa6c3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_69f3692ff6ad07ee554d357de78bd91e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3a19a3a862eb5e9218abc7b9687ef8ce
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2aadf9c83ec99d99c7073ca655ddb60f |
| publicationDate |
2017-07-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20170078843-A |
| titleOfInvention |
The sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates |
| abstract |
Spherical nucleic acids (SNA), consisting of dense packed and highly oriented polynucleotide strands attached to nanoparticle surfaces, can overcome difficulties in conventional nucleic acid delivery. The present disclosure demonstrates that G-enhanced SNAs show uptake into cells several times larger than SNAs in which the other nucleotides are increased. This disclosure is applicable to other nanoparticle systems and provides an effective strategy for maximizing the intracellular delivery of SNAs, which establishes important design considerations for nanoparticle-based intracellular delivery of therapeutic agents. |
| priorityDate |
2014-11-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |