abstract |
The present invention includes compounds of formula I: Formula I In this formula, R 1 , R 2 , R 3 , R 4 , R 5 , R 7 , R 8 and Are as defined herein. The invention also encompasses compounds of formula I for use in a method of treating or ameliorating a rheumatoid arthritis or psoriasis syndrome, disorder or disease. The present invention also encompasses compounds for use in a method of modulating RORĪ³t activity in a mammal by administering a therapeutically effective amount of at least one compound of claim 1. |