| abstract |
The present invention relates to certain compounds of formula (I) and to pharmaceutical compositions thereof that modulate the activity of cannabinoid CB 2 receptors. The invention also relates to certain compounds of formula (Ia) and to pharmaceutical compositions thereof that modulate the activity of both the CB 1 and CB 2 receptors. The compounds of the present invention and pharmaceutical compositions thereof are useful for the treatment of pain associated with pain and osteoarthritis, such as bone and joint pain, muscle pain, toothache, migraine and other headache pain, inflammatory pain, neuropathic pain, ; Hyperalgesia; Allodynia; Inflammatory hyperalgesia; Neuropathic hyperalgesia; Acute pain; osteoporosis; Multiple sclerosis-related stiffness; Autoimmune disorders; Allergic reactions; CNS inflammation; Atherosclerosis; Undesirable immune cell activity and inflammation; Age-related macular degeneration; cough; leukemia; Lymphoma; CNS tumors; Prostate cancer; Alzheimer's disease; Stroke-induced damage; dementia; Amyotrophic lateral sclerosis and Parkinson's disease. |