abstract |
The present invention relates to compounds. More particularly, the present invention relates to compounds useful as inhibitors of the Wnt signaling pathway. In particular, the present invention relates to inhibitors of Porcupine (Porcn). The invention also relates to processes for the preparation of the compounds and their use. The compounds of the present invention are useful for the treatment of conditions mediated by the Wnt signaling pathway, such as for the treatment of cancer, sarcoma, melanoma, skin cancer, hematologic tumors, lymphoma, carcinoma and leukemia; Or may be used to enhance the effectiveness of the chemotherapy. |