| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_465b607edb4c88aeefb4958e154efaec
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f402d1f8d42afe235f91a1b5c57b8c47
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_9d98762490c9bfd1551fefe55f49ea2c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_6b3e3de86fb3a7d008414342c8035051 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-531 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K48-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-113 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-30
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-36
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K48-00 |
| filingDate |
2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b4954f534b127945fdf513b6fceed957
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c4cc732d2172b9332a1adbb6867683c9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b0ad431eccc8d961c0d281a7e02f3a85
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_dbabe37ddb7e970568d96988fa515578
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e02b42d22594a1a8f25c59fdef6c7146
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_89ca3680b626f4be64ec6003527a8a8a |
| publicationDate |
2017-05-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20170055012-A |
| titleOfInvention |
Nanoparticles for genes drug delivery with siRNA for the long -term treatment of retinal disorders and method for preparing the same |
| abstract |
The present invention relates to a self-assembled and condensed high molecular weight siRNA core particle and a particle for efficiently delivering a large amount of siRNA into the inside of the retina by coating the outside with a cationic polymer and hyaluronic acid, and a method for producing the same. Since the core of the present invention contains at least 1 x 10 6 small interfering RNA (siRNA) or antisense nucleic acids, it can deliver a larger amount of siRNA than the conventional one. By coating the outer shell with (-) charged hyaluronic acid, it is possible to prevent aggregation with the vitreous meshwork structural materials having (-) charge and reach the inner limiting membrane of the retina. In addition, hyaluronic acid binds to the CD44 receptor of Muller cells, allowing the structure of the retina to pass through the sub-retinal space through the transcytosis mechanism. Some of them inhibit the translation of target gene mRNA in Muller cells, and many of them bind to the CD44 receptor present in the retinal pigment epithelial (RPE) cell membrane and enter the cell to analyze the mRNA of the target gene in RPE translation. |
| priorityDate |
2017-04-07-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |