abstract |
The present invention relates to a national drug of monophosphate nucleotides of the well-known tumor drug gemcitabine. Specifically, the present invention relates to gemcitabine- [phenyl-benzyl-L-alaninyl)] -phosphate when present in the form of a single phosphate diastereoisomer, and in particular, (S) -phosphate diastereomer that provides a noticeable and unexpected rise. The (S) -phosphate diastereomer is also preferentially absorbed in the cyclodextrin solution rather than the (R) -diastereomer. |