| abstract |
The present invention relates to a peptide including an amino acid sequence represented by general formula, X1-Leu-X2-Glu-X3-Glu-X4, and showing a proliferation activity of fibroblasts and keratinocyte constituting skin, and to a use of the same. In general formula, X_1 is Met, Ile, Phe, His, Lys, Arg, Glu, or Ile. X_2 is Lys ,Arg, His,, or Asn. X_3 is Trp ,Gly His, Tyr, or Arg. X_4 is Leu ,Asp, Asn, or Phe. Compared to a natural-type EGF, a skin cell proliferating peptide of the present invention has an identical skin cell proliferating ability and has a low molecular weight, thereby having very excellent skin transmittance. Accordingly, a composition including the peptide according to the present invention exhibits a very excellent effect in treating, preventing, or alleviating disease or states requiring an EGF activity, and can be applied to medical, quasi-drug, and cosmetic products. |