http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170022598-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_89063d5fcadc27223898e77276bc70d8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-0048 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4704 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4704 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K47-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K9-00 |
| filingDate | 2015-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_547be0bc725b191dd4b5af56633d348d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_39404387c2274d7aedc230b82ff1e189 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d15bce25903809d138ad9319d4991ea1 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_482a40d635224a8eb345dc09f843ab9c |
| publicationDate | 2017-03-02-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20170022598-A |
| titleOfInvention | Method for solubilizing Rebamipide and a solution for treating dry eye syndrome prepared thereby |
| abstract | (A) dissolving rebamipide or a pharmaceutically acceptable salt, cyclodextrin or cyclodextrin derivative thereof, and a base in water to obtain a solution having a pH of at least 8.5; And (b) adjusting the pH of the solution obtained in step (a) to a pH of 7 to 8.5, and a solution for treating dry eye syndrome produced by the method. Not only is rebamipide completely dissolved in a clear aqueous solution state by the solubilizing method of the present invention, the liquid preparation produced by the solubilizing method maintains a stable solution formulation even after 2 months in the accelerated test, And improved bioavailability with increasing absorption and persistence of rebamipide in conjunctiva. Therefore, the aqueous solution prepared by the solubilization method of the present invention can be effectively used as a solution for treating dry eye syndrome including rebamipide. |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20230011669-A http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2022092896-A1 |
| priorityDate | 2015-08-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 62.