| abstract |
The present invention provides a dosage form comprising at least one type of pentadol and at least one opioid antagonist, with or without a secondary analgesic agent, wherein the pentadol has an optimal or suboptimal And the antagonist is present in an amount effective to improve the efficacy of the pentadol and / or to reduce side effects of the other pentadol. The present invention also relates to a method of treating pain and pain associated conditions by administering to a patient in need thereof a dosage form comprising at least one form of pentadol and at least one opioid antagonist with or without a secondary analgesic agent, Wherein said antagonist is present in an optimal or sub-optimal amount and said antagonist is effective to improve the efficacy of < RTI ID = 0.0 > and / or < / RTI ≪ / RTI > |