| abstract |
The present invention is directed to 2-oxo-2,3-dihydro-indole of formula (I), or a pharmaceutically acceptable salt, racemic mixture, or a corresponding enantiomer and / or optical isomer and / or stereoisomer thereof It is about: (I) In this formula, Ar 1 is phenyl or a 5 or 6 membered heteroaryl group containing 1, 2 or 3 heteroatoms selected from N, S or O, wherein the N-heteroatom in the heteroaryl group is N + - (O - ) Can be oxidized; R 1 is lower alkyl, halogen, cyano or cycloalkyl; Ar 2 is a 5 or 6 membered heteroaryl group containing 1, 2, 3 or 4 heteroatoms selected from N, S or O, wherein the N-heteroatom in the heteroaryl group is oxidized to N + - (O - ) Or Ar < 2 > is benzo [b] thiophenyl; R 2 is selected from the group consisting of hydrogen, lower alkyl, halogen, cyano, lower alkyl substituted with hydroxy, lower alkyl substituted with halogen, lower alkyl substituted with amino, lower alkyl substituted with alkoxy, Cycloalkyl; X is CH or N; n is 1 or 2; m is 1 or 2; The compounds are useful for the treatment and / or prevention of schizophrenia, including, but not limited to, positive symptom (psychosis) and negative symptoms, drug abuse, alcohol and drug addiction, obsessive compulsive disorder, cognitive impairment, bipolar disorder, mood disorder, major depression, , Parkinson's disease, chronic pain, borderline personality disorder, neurodegenerative disease, sleeping disorder, chronic fatigue syndrome, stiffness, inflammatory disease, asthma, Huntington's disease, ADHD, amyotrophic lateral sclerosis, , Viral and fungal infections, cardiovascular diseases, ophthalmic and inflammatory retinal diseases or balance disorders. |