| abstract |
The present invention relates to a double-stranded nucleic acid as a drug, wherein the antisense strand has a sequence of a base complementary to a sequence of at least 19 contiguous bases of the mRNA of the CKAP5 gene of any one of SEQ ID NOS: 1-6, (Wherein R 1 and R 2 are the same or different and each is a straight or branched alkyl, alkenyl or alkynyl having 12 to 24 carbon atoms, L 1 and L 2 are the same or different and are -CO-O - or -O-CO-, a and b are the same or different and each is 1 to 3, and R 3 is a hydrogen atom, an alkyl having 1 to 6 carbon atoms or an alkenyl having 3 to 6 carbon atoms A composition for inhibiting the expression of CKAP5 gene containing lipid particles containing lipids, and a medicament comprising the composition. |