| abstract |
Solid drug core inserts may be prepared by injecting a liquid mixture comprising a therapeutic agent and a matrix precursor into the sheath body. The implantation can be performed at a temperature below the ambient temperature. The mixture is cured to produce a solid drug-matrix core. The therapeutic agent may be a liquid at about room temperature that forms a dispersion of droplets in the matrix material. The surface of the solid drug core is exposed, for example, by cutting the tube, and at the exposed surface of the solid drug core releases the therapeutic agent into the patient when injected into the patient. In some embodiments, the insert body inhibits release of the therapeutic agent, e.g., with a substantially non-transmissive material, such as a therapeutic agent, such that the therapeutic dose is released only through the exposed surface to prevent release of the therapeutic agent to the non-target tissue. |