http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20170002623-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4725 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P21-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P15-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D487-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-437 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4162 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 |
| filingDate | 2015-04-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a623f36b266554b737520d8841b26f4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6617f8d3e0ddda0dc53d719ee5a1a50 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fa2a79327745a98005ae22ae504f5a61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86644adef04877f470858eb0dd4e836f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b11e5e81f02b90a1c9d79410c2514d8 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1cd804c5a49e7869de829585b4944c59 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ac39ee4b9e488561894c3ff23c235374 |
| publicationDate | 2017-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20170002623-A |
| titleOfInvention | Pyrazolopyridines and pyrazolopyrimidines |
| abstract | A compound having the structure: or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of such a compound or a pharmaceutically acceptable salt. (I) Wherein A and A 'are independently C or N, wherein C may be unsubstituted or substituted by halo or C 1 -C 6 alkyl; R and R 0 are independently selected from H, C 1 -C 6 alkyl, hydroxy (C 1 -C 6 alkyl), phenyl (C 1 -C 6 alkyl), and - from a (CH 2) n -W group consisting of Wherein W is selected from the group consisting of C 3 -C 8 cycloalkyl, phenyl, naphthyl, 5- or 6-membered heteroaryl or heterocyclic containing 1-3 N, S and / or O atoms, -SO 2 -R ', -NHSO 2 -R', -NR "SO 2 -R 'and SR' wherein R 'and R" are independently C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl and the like; Wherein each of said alkyl, cycloalkyl, heterocyclic, phenyl, naphthyl or heteroaryl may be unsubstituted or substituted by phenyl, heteroaryl, or the like; Or R and R o and the N atom to which they are attached together form a monocyclic or bicyclic heterocyclic ring which is unsubstituted or substituted by one or more substituents selected from the group consisting of (a) halo, hydroxy, heteroaryl, C 1 -C 6 alkyl , C 1 -C 6 alkoxy and the like, or (b) - (CH 2 ) n -W, wherein W is C 3 -C 8 cycloalkyl, phenyl and the like; R < 1 > is H, halo or cyano; R 2 and R 2 ' are independently H, C 1 -C 6 alkyl, cyano, C 1 -C 6 alkoxy, C 1 -C 6 alkylthio, or C 3 -C 8 cycloalkyl, , Or cycloalkyl is optionally substituted by one or more fluorine atoms; X is a bond, -CO-, -CONH-, -SO 2 - , -SONH-, or - (CH 2) m -, and; R 3 is H, C 1 -C 4 alkyl, phenyl, naphthyl, 5- or 6-membered heteroaryl containing 1-3 N atoms or heterocyclic, 5-membered heteroaryl or heterocyclic, Or (c) two O or S atoms and 0-2 N atoms; Wherein each said phenyl, naphthyl, heteroaryl or heterocyclic is optionally substituted by 1 to 4 substituents each independently selected from alkyl, 1 substituent-YR 4, and / or R 5 ; With the proviso that X is -CO- or -SO 2 - in the case of, R 3 is not a H; Y is a bond, - (CH 2 ) m - or -O-; R 4 is (a) H, C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, halo, oxo, -OR 6, -NR 7 R 8 , -SR 6, -SOR 9, -SO 2 R 9 , -COR 6 , -OCOR 6 , -COOR 6 , -NR 6 COR 6 , -CONR 7 R 8 and the like; (b) phenyl or naphthyl, said phenyl and naphthyl being optionally substituted with one or more substituents selected from C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, halo, cyano, -OR 6 , -NR 7 R 8 , Lt; / RTI > Or (c) 3- to 8-membered saturated or partially unsaturated monocyclic heteroaryl and the like; R 6 is H, C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl and the like; R 7 and R 8 are each independently H, C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl, or together with the nitrogen atom to which they are attached, 1 or 2 nitrogen atoms or 1 nitrogen and 1 oxygen atom Wherein said C 1 -C 6 alkyl is optionally substituted by C 3 -C 8 cycloalkyl, halo, and the like, said heterocyclic ring being optionally substituted with one or more substituents selected from the group consisting of Optionally substituted by one or more C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl groups; R 9 is C 1 -C 6 alkyl or C 3 -C 8 cycloalkyl; m and n are independently 0, 1, 2 or 3; The present invention also relates to pharmaceutical acceptable salts of these compounds and pharmaceutically acceptable solvates thereof; A composition containing such a compound; And the use of such compounds in the treatment of various diseases, particularly asthma and COPD. |
| priorityDate | 2014-05-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 899.