| abstract |
Disclosed are compounds having drug and bio-affinity, pharmaceutical compositions thereof and methods of use. In particular, triterpenoids with inherent antiviral activity, represented by the compounds of formula (I), are provided as HIV maturation inhibitors: X is C 4-8 cycloalkyl, C 4-8 cycloalkenyl, C 4-9 spiro-cycloalkyl, C 4-9 spiro cycloalkyl alkenyl, C 4-8 oxa-cycloalkyl, C 4-8 cycloalkyl-dioxa , C 6-8 oxa-cycloalkenyl, C 6-8 dioxa cycloalkenyl, C 6 cycloalkyl Diallo alkenyl, C 6-oxa-bicyclo Diallo alkenyl, C 6-9 cycloalkyl, and C 6-9 spiro-oxa-oxaspiro cycloalkenyl / RTI > wherein X is substituted by A, and A is -Ci- 6 alkyl-halo. Such compounds are useful for the treatment of HIV and AIDS. |