| abstract |
The present invention provides a method for screening and detecting substantial organ explant rejection in a subject comprising analyzing a patient sample of plasma, serum or blood from the subject for a protein marker identified herein. An elevated or reduced amount of a marker present in the patient sample relative to a control sample indicates rejection and identifies a subject in need of biopsy or modified therapy. The method can be used to screen patients at risk of graft rejection without experiencing more expensive, risky, and invasive biopsy procedures. |