| abstract |
Compositions and methods related to or derived from anti-CD147 antibodies are disclosed. More specifically, there is disclosed a CD147-binding polypeptide comprising a fully human antibody, a CD147-binding fragment and a derivative of said antibody, and said fragment that binds to CD147. In addition, there is further provided a nucleic acid encoding said antibody, antibody fragment and derivative and polypeptide, a cell comprising said polynucleotide, a method of producing said antibody, antibody fragment and derivative and polypeptide, and a method of producing a CD147-associated disorder or condition Methods of using the antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing a subject, are disclosed. CD147-expressing tumors, including hepatocellular carcinomas and squamous cell carcinomas, and non-tumors selected from the group consisting of rheumatoid arthritis, experimental lung injury, atherosclerosis, chronic liver disease induced by hepatitis C virus, ischemic myocardial damage and heart failure Methods of treating diseases are also disclosed. |