Predicate |
Object |
assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94 |
classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-3809 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-6854 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/B01D15-168 |
classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/B01D15-38 |
filingDate |
2015-03-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0725c120dea8e2825bf82300cd9c9304 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_94688b5b3034f74a50d982b8781fb061 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d179d93bcff8b648cc53690c6bc4eb1f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5e9befd6d6c08cde4b8e37c53efdc6c8 |
publicationDate |
2016-11-23-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber |
KR-20160134687-A |
titleOfInvention |
In vitro prediction of in vivo half-life of antibodies |
abstract |
Comprising the steps of: a) measuring the retention time of the antibody on an FcRn affinity chromatography column in the shipment for positive linear pH gradient in the presence of a sodium chloride concentration, b) measuring a positive linear pH gradient in the presence of sodium chloride concentration Fc-FcRn interaction in an antibody-Fc-FcRn complex affecting the in vivo half-life, comprising measuring the residence time of the antibody on the FcRn affinity chromatography column Wherein the presence of antibody-Fab-FcRn interaction in the antibody-Fc-FcRn complex affecting in vivo half-life, when the retention time measured in step a) is substantially different from the residence time measured in step b) Have been reported. |
priorityDate |
2014-03-21-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type |
http://data.epo.org/linked-data/def/patent/Publication |