abstract |
The present invention relates to a compound of formula I, or a pharmaceutically acceptable salt or composition thereof, a method of use and a method for the preparation of an inhibitor of complement factor D. The inhibitors described herein target Factor D and inhibit or modulate complement cascade in early and critical points in other complement pathways and reduce the ability of Factor D to modulate a typical Lectin complement pathway. Inhibitors of factor D described herein may reduce certain autoimmune, inflammatory and neurodegenerative diseases, and excessive activation of complement associated with ischemic reperfusion injury and cancer. |