abstract |
The present invention provides a compound of formula I wherein R 12 or R 13 is an amide substituent (R 32 ), or a pharmaceutically acceptable salt or composition thereof, wherein said compound is an inhibitor of complement factor D, . The inhibitors described herein target Factor D and inhibit or modulate complement cascade in early and critical points in other complement pathways and reduce the ability of Factor D to modulate a typical Lectin complement pathway. Inhibitors of factor D described herein can reduce excessive activation of complement, which is associated with certain autoimmune, inflammatory and neurodegenerative diseases, and ischemic reperfusion injury and cancer. |