| abstract |
The invention provides a compound of formula I wherein R 12 or R 13 is aryl, heteroaryl or heterocycle (R 32 ), or a pharmaceutically acceptable salt or composition thereof, which is an inhibitor of complement factor D, A method of using the same, and a manufacturing method. The inhibitors described herein target Factor D and inhibit or modulate complement cascade in early and critical points in other complement pathways and reduce the ability of Factor D to modulate a typical Lectin complement pathway. Inhibitors of factor D described herein can reduce excessive activation of complement, which is associated with certain autoimmune, inflammatory and neurodegenerative diseases, as well as ischemic reperfusion injury and cancer. |