| abstract |
A is a substituted or unsubstituted aryl or heteroaryl group, D is a substituted or unsubstituted 5-or 6-membered heteroaryl or heterocyclyl group, E is substituted or unsubstituted aryl, heteroaryl, cyclo Alkyl, or a heterocyclyl group. The present compounds are useful for the treatment of androgen-regulated indications including cancer (prostate cancer, breast cancer, ovarian cancer, endometrial cancer, or bladder cancer), hair loss, acne, hirsutism, ovarian cysts, polycystic ovary disease, Is used. The use of compounds in the manufacture of medicaments for modulating AR activity, methods of treatment using these compounds, and pharmaceutical compositions and commercial packages comprising the compounds are also described. |