| abstract |
It is an object of the present invention to provide a novel useful vitamin D3 derivative having excellent vitamin D3 activity and little effect on systemic calcium metabolism. As the present invention, there can be mentioned a 9,10-secopregnene derivative represented by the following formula (1) and a pharmaceutical composition containing it as an active ingredient. Formula 1 (2) alkylene, (3) alkenylene or (4) phenylene, R 1 and R 2 are the same or different and are selected from the group consisting of (1) hydrogen, (2) Alkyl or (3) cycloalkyl, or R 1 and R 2 together with the adjacent carbon atom represent cycloalkyl, R 3 represents hydrogen or methyl and Z represents (1) hydrogen, (2) hydroxy or 3) -NR 11 R 12 . |