| abstract |
The present invention relates to a monoclonal antibody or antigen-binding portion thereof that specifically binds to the C-terminal or central region of a macrophage migration inhibitory factor (MIF). These anti-MIF antibodies and their antigen-binding portions further inhibit the biological function of human MIF. The present application also relates to isolated heavy and light chain immunoglobulins derived from anti-MIF antibodies, and to nucleic acid molecules encoding such immunoglobulins. The present application also relates to methods of identifying anti-MIF antibodies, pharmaceutical compositions comprising these antibodies, and methods of using these antibodies and compositions for the treatment of MIF-related conditions. |