| abstract |
The present invention relates to an aerosol solution composition for use with a pressurized metered dose inhaler (pMDI), wherein glycopyrronium bromide and formoterol, or a salt thereof, optionally in combination with one or more additional active ingredients, In an aerosol can with a metering valve having at least one butyl rubber gasket so as to be stabilized by the amount of mineral acid selected and at least three months under an acceleration condition of 25 DEG C and 60% relative humidity (RH) (3-bromo) - [2-hydroxy-5- [1-hydroxy-2- [1- (4-methoxyphenyl) ] Phenyl] formamide is lower than the quantitation limit. One or more optional active ingredients are selected from the group consisting of beclomethasone dipropionate, budesonide or its 22R-epimer, cyclosonide, flunisolid, fluticasone propionate, fluticasone furoate, ≪ / RTI > and the like. |