| abstract |
The present application discloses a monoclonal antibody or a binding portion thereof that specifically binds to a Staphylococcus species disintegrating N-acetyl muramoyl-L-alanine amidase catalytic domain and / or a cell wall binding domain, as well as a pharmaceutical composition containing the same . Cell lines expressing monoclonal antibodies, including hybridomas, are also disclosed. Diagnostic methods for the detection of Staphylococcus in a sample can be achieved by using monoclonal antibodies for the installation of orthopedic implants, grafts or medical devices, treating or preventing staphylococcus infection, treating osteomyelitis . |