http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160094478-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_545ef293d341e1d23a695a05645dc39c |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-506 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-506 |
| filingDate | 2015-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_01e855acd0cab1944c00ad0bd0598d2e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_bc41822be1de3528f36e5ba96b210c06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_16a0f23f1778a6177b6e25d74ac4cf8a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_deeb4d8b1eadc3df99092716aa322a3f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_505743a4003a6aca49577d63f1f0f227 |
| publicationDate | 2016-08-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20160094478-A |
| titleOfInvention | Manufacturing method of taltirelin using polymer solid support |
| abstract | The present invention relates to an effective method for preparing a taltirelin compound or a pharmaceutically acceptable salt thereof, and the purpose of the present invention is to obtain a final compound with an HPLC purity of 99% or more through simple crystallization. The method comprises: (1) a first step for coupling Fmoc-proline with a polymeric solid support; (2) a second step for coupling Fmoc-histidine with the polymeric solid support; (3) a third step for coupling 1-methyl-4,5-dihydroorotic acid with the polymeric solid support; (4) a fourth step for separating prepared peptide from the polymeric solid support using trifluoroacetic acid (TFA); and (5) a fifth step for neutralizing the peptide separated from the polymeric solid support and precipitating the peptide using an organic solvent. |
| priorityDate | 2015-01-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 78.