http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160089130-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_44f04d319aaa6e66f240244bc905f452 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-04001 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y301-21 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12Q1-44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-16 |
| filingDate | 2015-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b6883f2b43f72892aaf890059b1bea6 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7c802b8bb7f2c867f1c74016b9fd6921 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a7eb067dc40252aa1e9e839b7aaddc4c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_992b10144cb00c017d14e468a9517023 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3600909658d2dee8c460820d51ec8e6 |
| publicationDate | 2016-07-27-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20160089130-A |
| titleOfInvention | Crystal of fan1-5' flap dna complex and method of manufacturing the same |
| abstract | The present invention relates to a crystal structure of a novel complex formed by binding FAN1 (Fanconi anemia associated nuclease 1) protein and 5 'terminal plective nucleic acid (5' flap DNA) and a method for producing the same, and more specifically, The present invention relates to a three-dimensional complex crystal structure in which FAN1 derived from Psuedomonas auresinosa is expressed and purified, and then the 5'-end plectranucleic acid, which is a target substrate of FAN1, is bound. Since the FAN1-5'preplicate nucleic acid complex according to the present invention exhibits high sensitivity to an interstrand cross-link induced anticancer drug by inhibiting the nucleic acid cleavage activity of FAN1, it is useful for developing an anticancer drug with increased efficiency Can be used. |
| priorityDate | 2015-01-19-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 89.