abstract |
A) a HCl salt of compound ( 1 ) .xH 2 O, wherein x is from 0 to 3, based on the weight of the pharmaceutical composition, from 5 wt% to 95 wt%; And b) from 5 wt% to 95 wt% filler based on the weight of the pharmaceutical composition. Another pharmaceutical composition comprises a) 1 mg / mL to 20 mg / mL of compound ( 1 ) in water; And b) 0.01M to 0.1M of a pharmaceutically acceptable pH adjusting agent. Method of manufacturing a pharmaceutical composition, the compound (1) with a mixture of fillers comprising the HCl salt of the compound (1) • xH 2 O comprises providing. Another method for preparing a pharmaceutical composition comprises mixing 1 mg / mL to 20 mg / mL of the compound ( 1 ) in water by mixing the HCl salt of the compound ( 1 ) xH 2 O with a pH adjusting agent. Methods for reducing the amount of influenza virus, inhibiting replication of influenza virus, and treating influenza, each independently use the pharmaceutical composition. |