| abstract |
The present invention relates to a drug complex using a repebody derivative and a method for preparing the same. More particularly, the present invention relates to a drug complex comprising a VLR (leucine-rich repeat) family protein having an alpha helical capping motif at its N- a lymphoid ligand conjugate in which a LRR structure derived from a variable lymphocyte receptor is ligated to a variable region and a substance having an activity such as a drug, a toxin, a ligand and a detection marker is conjugated to a lipid body exhibiting substrate specificity , RDC) and a method for producing the same. The RDC according to the present invention is a compound having high substrate specificity, excellent tissue and tumor penetration ability, and biological activity provided by Lipid body, and thus has superior efficacy compared to the case of using lipofibody alone. And has the advantage of having a specific selectivity compared with the use of a tumor cell. By using this, it is possible to selectively kill only cancer cells by binding a toxin that kills a cell to a lipid body that specifically binds to a protein over- It is expected to be utilized. |