| abstract |
The present invention relates to a composition for alleviating renal toxicity caused by an immunosuppressive agent comprising metformin and a composition for preventing or treating immunological diseases comprising the same, and more particularly to a composition for preventing or treating immunological diseases comprising metformin, A composition for reducing renal toxicity, a pharmaceutical composition for preventing or treating an immunological disease comprising metformin and a calcineurin inhibitor as an active ingredient, and a metformin and a calcineurin inhibitor as components, which are administered simultaneously or separately Which comprises administering a pharmaceutical composition for the prevention or treatment of an immunological disease. The composition of the present invention can be effectively used for alleviating renal function deterioration caused by side effects of conventional immunosuppressants, thereby enhancing the therapeutic effect of diseases that require immunosuppression. Further, the composition of the present invention can be used in combination with existing immunosuppressants and metformin Methods can be used to reduce the renal toxicity side effects of existing immunosuppressants and to maximize immunosuppression or immunomodulating effects, thereby being useful for preventing or treating organ transplant rejection, autoimmune diseases, inflammatory diseases and the like. |