| abstract |
The present invention relates to an EFNA4 antibody-drug conjugate; And their use in the detection, prevention and treatment of EFNA4 related disorders. An EFNA4 antibody-drug conjugate of the invention is generally of the formula: Ab- (L-D) wherein Ab is an antibody that binds EFNA4, or an EFNA4-binding fragment thereof, or an antigen-binding fragment thereof; L-D is a linker-drug moiety, wherein L is a linker and D is a drug, preferably calicheamicin. Ab of the disclosed antibody-drug conjugates can be any EFNA4-binding antibody. In some aspects of the invention, the Ab is a chimeric, CDR-grafted, humanized, or recombinant human antibody, or an EFNA4-binding fragment thereof. In some aspects of the invention, the Ab is an internalizing antibody and / or a neutralizing antibody. |