| abstract |
Certain derivatives of Amphotericin B (AmB) are provided that are characterized by reduced toxicity and retained anti-fungal activity. Certain derivatives are C16 urea derivatives of AmB. Certain derivatives are C3, C5, C8, C9, C11, C13, or C15 deoxy derivatives of AmB. Certain derivatives include C3 'or C4' modifications of the mycosaminic appendages of AmB. Methods of making the AmB derivatives of the invention, pharmaceutical compositions comprising the AmB derivatives of the invention, and methods of using the AmB derivatives of the invention are also provided. |