| abstract |
The present invention relates to a cyclic peptide (cyclic [Cys-Gln-Arg-Pro-Pro-Arg-Cys] peptide) comprising the amino acid sequence shown in SEQ ID NO: 2, , A composition for imaging, and the like. (Cyclic [Cys-Gln-Arg-Pro-Pro-Arg-Cys] peptide) of the amino acid sequence shown in SEQ ID NO: 2 of the present invention binds (or targets) to apoptotic cells in comparison with the linear peptide. , Which greatly facilitates the detection of apoptotic cells and the imaging of lesions where apoptosis is under way in vivo and the detection and imaging signals are highly relevant in predicting disease prognosis. Accordingly, the cyclic peptide of the present invention binds to an imaging substance to initially diagnose the reactivity of a therapeutic drug against abnormal cell proliferation-related diseases, and can selectively bind a drug to a cell death related disease tissue in combination with a therapeutic substance Can be used. |