| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_067984ba98fa23673a8d8c8dcfb6425a |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-33
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-34
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-515
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-565
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-26 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K39-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-56938
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-1271 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-12
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-085
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-00 |
| filingDate |
2014-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_85e383f80129e079190c665b85c00a55
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf0e3a1e2d054a2142554395fb2a71cf
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_88fb1443cd0a91013cfa75252303fec6
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d6ff6d3fa40fb02eb16d13ac8815525
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9179316e76e9957cbd5cb0f941fc2237
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dfbd45ae161fd2a9d0f04ac368c89bb
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_53041e198886b00f7a0c7c1427aade90
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f4dbfcb3efc5b183ea32f5eb10665d9
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_47ac8a05cd976f37008f7fd97835e6d3
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9dcafc45a05ef44865cd20a120cf418e |
| publicationDate |
2016-06-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20160067977-A |
| titleOfInvention |
Cross-reactive staphylococcus aureus antibody sequences |
| abstract |
The present invention relates to a cross-neutralizing antibody comprising at least one multispecific binding site that binds to the alpha-toxin (Hla) of Staphylococcus aureus and to at least one two-component toxin, Wherein the antibody comprises at least three complementarity determining regions (CDR1 to CDR3) of the antibody heavy chain variable region (VH), wherein A) said antibody comprises: a) a CDR1 comprising or consisting of the amino acid sequence YSISSGMGWG (SEQ ID NO: 1); And b) a CDR2 comprising or consisting of the amino acid sequence SIDQRGSTYYNPSLKS (SEQ ID NO: 2); And c) a CDR3 comprising or consisting of the amino acid sequence ARDAGHGVDMDV (SEQ ID NO: 3); Or B) said antibody comprises: a) a parent CDR1 comprising the amino acid sequence of SEQ ID NO: 1; And b) a parent CDR2 consisting of the amino acid sequence of SEQ ID NO: 2; And c) a parent CDR3 consisting of the amino acid sequence of SEQ ID NO: 3; Wherein said functionally active CDR variant comprises or consists of an amino acid sequence comprising at least one point mutation in said parent CDR sequence and having at least 60% sequence identity to said parent CDR sequence. The present invention is also directed to such a cross-neutralizing antibody as a functionally active variant antibody of a parent antibody comprising a VH amino acid sequence of SEQ ID NO: 20 and a multispecific binding site of a VL amino acid sequence of SEQ ID NO: 39, antibody comprises at least one point mutations in any region of the framework regions (FR) or a constant domain, or SEQ ID NO: 20 and SEQ ID NO: complementarity determining regions (CDR1 to CDR6) of any of the sequences of the 39 and 10 -8 K, preferably less than 10 < -9 > M. |
| priorityDate |
2013-10-17-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |