| abstract |
In the present invention, X is CH 2 , oxygen or sulfur; R 1, R 2 and R 3 are the same or different and represent hydrogen, halogen, alkyl, alkyloxy, hydroxy, nitro, alkylcarbonylamino, alkylamino or dialkylamino group, wherein N is the individual (R) - and ( S ) or a compound of formula ( R ) - and ( S ) -. The present invention also provides compounds of formula MA. The present invention also provides methods of making such compounds, and methods comprising their use. This compound is particularly useful as a peripheral-selective inhibitor of dopamine-beta-hydroxylase. |