| abstract |
The present invention provides an immunoglobulin fusion protein comprising a first antibody region, a first therapeutic agent, and a first linking peptide, wherein the first therapeutic agent is attached by a linking peptide to the first antibody region, Wherein the immunoglobulin fusion protein does not comprise a region having a secondary structure. The linking peptide may comprise an extender peptide. Extender peptides can have a secondary structure of alpha helices. The linking peptide may comprise a linker peptide. Linker peptides may not contain any secondary structure. Also disclosed herein are methods of using an immunoglobulin fusion protein to treat or prevent a disease or condition in a composition and a subject comprising an immunoglobulin fusion protein. |