| abstract |
There is provided a method of synthesizing an influenza virus-like particle (VLP) in a plant or part of a plant. This method involves the expression of influenza HA in plants and purification by size exclusion chromatography. The present invention also relates to a VLP comprising an influenza HA protein and a plant lipid. The invention also relates to nucleic acids and vectors encoding influenza HA. VLPs can be used to produce influenza vaccines, or can be used to hatch existing vaccines. |