| abstract |
The present invention is generally directed to a host cell having an artificial host organism, wherein said artificial host organism and said host cell communicate with each other to alter the phenotype of said host cell. In some embodiments, the communication comprises secretion of the polypeptide into the host cell in the artificial host organism. The secreted polypeptide may be selected from the group consisting of a selectable marker, a reporter protein, a transcription factor, a signal pathway protein, a receptor, a growth factor, a cytokine, an action factor molecule, It can be an external argument. |