http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20160044140-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_e5351c62aee4203f2be2944f21a6def2 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2333-90219 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-7014 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-47 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-5011 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10 |
| filingDate | 2014-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f59624fd56081f7a01429a1834f5aee http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aae89199cb76686cbfb8b54396e18712 |
| publicationDate | 2016-04-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-20160044140-A |
| titleOfInvention | Construction of mitochondrial UQCRB mutant expressing cells and utilization of the cells for UQCRB assay system thereof |
| abstract | The present invention relates to a mitochondrial UQCRB mutant cell line expressing a UQCRB (Ubiquinol-cytochrome c reductase binding protein) mutant protein. The present invention provides a new method for evaluating the activity of UQCRB using a novel mitochondrial UQCRB mutant cell line. The present invention provides a method for evaluating anticancer activity, an assay for inhibiting angiogenesis, and a screening method for inhibiting UQCRB activity. In particular, the cell line of the present invention is a novel cell line having cell proliferation and angiogenesis inducing activity, and provides a screening method of an angiogenesis inhibitory substance or an anti-cancer substance through the inhibition mechanism of UQCRB activity, thereby providing an angiogenic or mitochondrial- And can be applied to the development of therapeutic agents for various cancers. |
| priorityDate | 2014-10-14-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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