abstract |
The present invention discloses compounds according to formula (I) Formula I Wherein R 1 , R 2 , R 3 , R 4 , L and X are as defined in the present invention. The present invention relates to compounds, methods for their preparation, pharmaceutical compositions comprising such compounds, and pharmaceutical compositions comprising such compounds and compositions for use in the treatment of inflammatory conditions, type 2 diabetes, neurological and / or neurodegenerative diseases, autoimmune diseases, proliferative diseases (particularly metastatic diseases and / , An abnormal angiogenesis-related disease, cartilage degradation and / or the prevention and / or treatment of collapse of cartilage homeostasis. The present invention also discloses methods of treatment using the compounds for the prophylaxis and / or treatment of the diseases by administering the compounds of the present invention. |