| abstract |
The present invention relates to a non-cytotoxic protease, wherein the protease is capable of cleaving the itch-specific DRG neurons or the SNARE protein in the somatic receptors; As a targeting moiety (TM) capable of binding to a binding site on an itch-specific DRG neuron or an oligosaccharide receptor, the binding site can be incorporated into the endosome within an itch-specific DRG neuron or anorexia receptor through intracellular entry, A targeting moiety (TM) wherein said itch-specific DRG neuron or somatosensory receptor expresses said SNARE protein; And a potential domain capable of translocating the protease from the endosomes through the endosomal membrane into the itch-specific DRG neurons or into the cytosol of the oligodendrocyte receptors, provided that the polypeptide is a clostridial neurotoxin Lt; / RTI > is not a molecule, for example, a toxin molecule. |