| abstract |
The present invention relates to derivatives of GLP-1 like peptides which are analogues extending towards the C-terminus of native GLP-1. The derivative comprises two side chains, one at a position corresponding to position 42 and one at a position corresponding to positions 18, 23, 27, 31, 36, or 38, both at GLP-1 7-37). The side chain includes a C19, C20, or C22 bicontinuous moiety and optionally a linker. The present invention also relates to intermediates in the form of novel GLP-1 analogs, as well as pharmaceutical compositions, and medicinal uses of derivatives, which are incorporated into the derivatives of the present invention. Derivatives have a very long half-life while maintaining satisfactory efficacy, which makes the derivatives potentially suitable for administration once a month. |