| abstract |
Controlled release pharmaceutical dosage forms for the treatment of dermatological conditions, methods for their preparation, and methods of use thereof. Provides a doxycycline formulation that is maintained and released in a controlled manner at the upper portion of the gastrointestinal tract. The formulations provide improved efficacy and reduced side effects and / or adverse effects when compared to conventional immediate release dosage forms of doxycycline. Previously, it has been reported that delaying the release of doxycycline reduces oral bioavailability of doxycycline, but surprisingly it has been surprisingly found that when administered in controlled release mode, the relative oral bioavailability It has been found that the utilization is orally bioavailable in excess of about 80%, in certain embodiments greater than about 90%. |