| abstract |
A stabilized a-CT polypeptide comprising an alpha-helical segment is provided herein, said polypeptide having the formula (I-1) or (1-2); <Formula I-1> ≪ Formula (I-2) > Said alpha-CT polypeptide binds to an insulin receptor; The α-CT polypeptide comprises at least one staple (ie, two bridged amino acids) and / or at least one stitch (ie, three bridged amino acids). Also provided are methods of treating an insulin analogue comprising a stapled or stitched alpha-CT polypeptide, pharmaceutical compositions thereof, methods of use thereof, such as diabetic conditions or complications thereof. [Representative figure] 5A and 5B |