| abstract |
Kits and methods for treating diseased tissues caused by viruses in mammals involve co-administration of topical administration of systemic anti-viral drugs, and anti-infective compositions. Systemic anti-viral drugs are administered into the body and then systemically disrupt or inhibit viral replication in mammals. Examples include nucleoside analogs, nucleoside analog precursors, and nucleotide analogs. The topically applied anti-infective composition comprises at least one anti-infective agent, such as an organohalide (e.g., benzalkonium chloride), which penetrates below the diseased tissue surface and causes the anti- To be killed. The anti-infective compositions reduce the time and / or the number of doses required for systemic anti-viral drugs to treat diseased tissue in the absence of topical administration of the anti-infective composition. The anti-infective composition also reduces or eliminates the incidence of neuralgia after treatment. |