| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_cbffa3b81b3b862dc7220b5648f5f745 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2330-50
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-141 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y204-0108
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P21-005
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-1051
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K14-505 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K14-00 |
| filingDate |
2014-07-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32503a9c5056bd16992492e22b1da8e8
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d5d998cfad93549b5aed4fdde29744fa
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_04b8caee1c66364cb4695e22a190e806
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_86e02c7669682308e8bdbbf094461e97 |
| publicationDate |
2015-12-30-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
KR-20150145673-A |
| titleOfInvention |
Method for preparing recombinant glycoproteins with high content of sialic acid by modulating glycosphingolipid biosynthesis pathway |
| abstract |
The present invention relates to a method for producing a recombinant cell line that produces a recombinant glycoprotein having a sialic acid content by inhibiting a biosynthetic pathway of glycospingolipid (GSL) in a cell line producing a recombinant glycoprotein, Specifically, siRNA and miRNA that specifically bind to ceramide glucosyltransferase (CGT) are used to generate erythropoietin (EPO) containing a high intracellular sialic acid in a cell line that induces CGT inhibition Can increase the half-life of the recombinant therapeutic protein and can be useful for the treatment of the disease. |
| isCitedBy |
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-20180016952-A
http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-2018030738-A1 |
| priorityDate |
2014-06-18-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |