| abstract |
The present invention provides an intermediate for the production of an art rope isomer of a pyrrole derivative having a corticoid receptor antagonistic action with excellent minerals, a process for producing the same, and a crystal thereof. (I), which is characterized by using an optically active amine having a cinchonane skeleton, [In the formula, R 1 represents a methyl group or a trifluoromethyl group, R 2 represents a hydrogen atom or a C 1 -C 3 alkoxy group, and n represents an integer selected from 1 to 3] (S) -1- (2-hydroxyethyl) -4-methyl-N- [4- (methylsulfonyl) phenyl] -5- [2- Trifluoromethyl) phenyl] -1H-pyrrole-3-carboxamide. |