| abstract |
The present invention relates to substituted oxopyridine derivatives of formula (I), and methods for their preparation and for the treatment and / or prophylaxis of diseases, especially cardiovascular diseases, preferably thrombotic or thromboembolic diseases, and edema, And to its use for the manufacture of medicaments. (I) In this formula, R 1 is a group of the formula: Wherein * is the attachment site to the oxopyridine ring, R 6 is bromine, chlorine, fluorine, methyl, difluoromethyl, trifluoromethyl, methoxy, difluoromethoxy or trifluoromethoxy, R 7 is selected from the group consisting of bromine, chlorine, fluorine, cyano, nitro, hydroxyl, methyl, difluoromethyl, trifluoromethyl, methoxy, ethoxy, difluoromethoxy, trifluoromethoxy, ethynyl, 3,3,3-trifluoroprop-1-yl-1-yl or cyclopropyl. |